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check with your physician before you take any of the following medications amiodarone cordarone ; digoxin lanoxin, lanoxicaps, digitek ; metformin glucophage, glucovance ; megestrol megace ; diltiazem cardizem, others ; zafirlukast accolate ; quinine; fluconazole diflucan ; erythromycin; clarithromycin biaxin ; norfloxacin noroxin , gatifloxacin tequin , moxifloxacin avelox and other fluoroquinolone antibiotics; fluoxetine prozac , sertraline zoloft , paroxetine paxil and other selective serotonin reuptake inhibitors; furosemide lasix , triamterene dyrenium , amiloride midamor and other diuretics; indinavir crixivan and other protease inhibitors.

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one mechanism of drug interaction with digoxin is change in absorption due to increased contact time in the small intestine.

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absorption following oral administration, peak serum concentrations of digoxin occur at 1 to 3 hours.

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if too much of the medication is provided, it may not be processed out of the body, leading to a digoxin overdose or digitalis toxicity, which could result in death.

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