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In an open-label, randomized, placebo-controlled trial in 22 healthy male volunteers, the administration of a single 1 mg dose of doxazosin on day 1 of a four-day regimen of oral cimetidine 400 mg twice daily resulted in a 10 increase in mean auc of doxazosin, and no statistically significant changes in mean cmax and mean half-life of doxazosin.

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