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methotrexate used to treat certain types of cancer, arthritis or psoriasis at doses greater than 20 mg week,.

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methotrexate may cause an increased risk for infertility, not birth defects.

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avoid drinking alcohol while taking methotrexate.

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excellent correlation has been reported between methotrexate clearance and endogenous creatinine clearance.

Basic pharmacology methotrexate is a folate antimetabolite that inhibits di- phenylbutazone-type drugs hydrofolate reductase and other folate-dependent en- the phenylbutazone-type drugs include phenylbuta- zymes in cells.

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