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Your doctor may tell you that you should not take methotrexate unless you have life-threatening cancer.

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literature suggests that concomitant use of ppis with methotrexate primarily at high dose may elevate and prolong serum levels of methotrexate and or its metabolite, possibly leading to methotrexate toxicities.

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in clinical trials, arava was less or equally effective as methotrexate, a drug commonly used to treat the painful and swollen joints of rheumatoid arthritis, public citizen said, adding that fewer serious reactions have been reported with methotrexate.

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the terminal half-life reported for methotrexate is approximately three to ten hours for patients receiving treatment for psoriasis, or rheumatoid arthritis or low dose antineoplastic therapy less than 30 mg m .

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